Figure 1. Performance comparisons between PRMDA and five advanced disease-miRNA association prediction models (HGIMDA, RLSMDA, HDMP, WBSMDA, and RWRMDA) in terms of ROC curve and AUC based on the framework of LOOCV.

As a result, PRMDA achieved AUC of 0.8315 in LOOCV, significantly outperforming all the previous computational models in prediction accuracy.