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. 2017 Aug 24;8(49):85628–85641. doi: 10.18632/oncotarget.20429

Figure 6. Clinical analysis of IHC staining of osteosarcoma samples.

Figure 6

(A) Representative images of IHC staining for low (left) and high (right) p-Src expression levels. (B) Kaplan-Meier curve showing that lower expression of p-Src is significantly associated with an improved prognosis (P < 0.05). (C) Scores of IHC staining for p-Src and p-Akt are positively associated (upper panel, Bars, mean±SEM, *P < 0.05); meanwhile, those for p-Src and Nanog are also positively associated (lower panel, Bars, mean±SEM, *P < 0.05). (D) Schematic summarizing our findings. In OS cells, higher Nanog expression significantly enhances stemness, motility and chemoresistance. TSSC3 inhibits Src activity, resulting in decreased activity of the Akt pathway and leading to a reduction in Nanog expression and stem-like phenotype in OS cells.