Table 7. miRNA expression either in lung or blood serum of 7.5-month old Swiss mice of both genders exposed to MCS during the first 4 months of life and treated with naproxen after weaning, as related to microadenoma multiplicity.
| miRNA | Lung | Blood | Main regulated functions |
|---|---|---|---|
| miR-16 | 4.20 | Apoptosis | |
| miR-27a | 4.59 | Cell proliferation, stress response, protein repair | |
| miR-30 | 0.19 | Intercellular adhesion, protein repair, NFkB activation, cell cycle, EGF activation, stem cell recruitment, multidrug resistance, mammary gland development | |
| miR-92a | 6.35 | DICER regulation | |
| miR-101 | 4.56 | COX activation | |
| miR-133a | 3.26 | Inflammation | |
| miR-137 | 4.88 | Cell proliferation, COX-2 negative regulator | |
| miR-181b | 3.32 | 1.30 | NFκB stress response |
| miR-148b | 4.03 | Apoptosis, tumor suppressor in hepatocellular carcinoma | |
| miR-186 | 6.06 | Modulates PTTG1 protein expression (function in NSCLC invasion/metastasis) | |
| miR-203b | 5.55 | Cell proliferation, angiogenesis | |
| miR-301a | 0.27 | Stress response, oncogene activation | |
| miR-324 | 1.32 | Induces promoter-mediated expression of the RelA gene | |
| miR-331 | 3.23 | Inhibits expression of neuropilin-2, a receptor implicated in neuronal development | |
| miR-344b | 3.25 | Cell plasticity, influences the expression of genes involved in one-carbon metabolism (DNA synthesis and methylation, amino acid metabolism) and cell proliferation | |
| miR-344d | 1.49 | Cell plasticity, influences the expression of genes involved in one-carbon metabolism (DNA synthesis and methylation, amino acid metabolism) and cell proliferation | |
| miR-344e | 6.15 | Influences the expression of genes involved in one-carbon metabolism (DNA synthesis and methylation, amino acid metabolism) and cell proliferation | |
| miR-344f | 3.18 | 1.33 | Neural development, influences the expression of genes involved in one-carbon metabolism (DNA synthesis and methylation, amino acid metabolism) and cell proliferation |
| miR-363 | 6.40 | Cardiac cell differentiation, expression of endothelial cell-specific genes | |
| miR-375 | 3.75 | Inflammation (prostaglandin activation), Cell differentiation | |
| miR-380 | 4.27 | Represses p53 to control cell survival | |
| miR-409b | 3.22 | - | |
| miR-455 | 3.10 | TGF signaling, enhances cancer growth and metastasis in vivo | |
| miR-466a | 1.42 | Involved in fatty acid metabolism | |
| miR-487b | Promotes endothelial cell proliferation, migration, and invasion | ||
| miR-499a | Cell proliferation, cell differentiation | ||
| miR-532 | 3.85 | Gene transcription, apoptosis | |
| miR-543 | Stress response, inflammation | ||
| miR-551b | 1.47 | DNA repair, inflammation, cell proliferation | |
| miR-664b | Decreases MAPK-1 expression which reduces TNF-α | ||
| miR-708 | 3.04 | 0.62 | Stress response, NFkB activation |
The numbers indicate the ratio of miRNA expression (fold-variation) between mice bearing <10 vs. >10 microadenomas.