Table 8. miRNA expression either in lung or blood serum of 7.5-month old Swiss mice of both genders exposed to MCS during the first 4 months of life and treated with naproxen after weaning, as related to the presence of lung adenomas.
| miRNA | Lung | Blood | Main regulated functions |
|---|---|---|---|
| miR-30b | 0.27 | Intercellular adhesion, protein repair, NFkB activation, cell cycle, EGF activation, stem cell recruitment, multidrug resistance | |
| miR-30c | 0.47 | Intercellular adhesion, protein repair, NFkB activation, cell cycle, EGF activation, stem cell recruitment, multidrug resistance | |
| miR-101b | 1.86 | COX activation | |
| miR-125b | 0.31 | Oncogene ERBB regulation, vitamin D receptor, inflammation | |
| miR-206 | 0.27 | Myoblast differentiation and proliferation | |
| miR-291a | 0.47 | Differentiation of embryonic stem cells | |
| miR-344b | 4.83 | Cell plasticity | |
| miR-344h | 2.05 | Cell plasticity | |
| miR-483 | 5.45 | Epithelial-mesenchymal transition, prometastatic fuction (RhoGDI1 and ALCAM regulation), angiogenesis-inhibiting factor | |
| miR-711 | 0.1 | 0.52 | Tissue fibrosis |
The numbers indicate the ratio of miRNA expression (fold-variation) between adenoma-bearing vs adenoma-free mice.