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. 2017 Aug 24;8(49):85749–85758. doi: 10.18632/oncotarget.20479

Figure 2. In vitro and in vivo analysis of the tumor suppressor function of ZNF154 in nasopharyngeal cancer (NPC).

Figure 2

(A) Ectopic overexpression of ZNF154 in C666-1 and 5-8F cells. (B) ZNF154 did not suppress the viability of C666-1 or 5-8F cells. (C) Overexpression of ZNF154 did not significantly affect NPC cell line growth or colony formation. (D) Overexpression of ZNF154 inhibited NPC cell migration in the wound healing assay. (E) Overexpression of ZNF154 inhibited NPC cell invasion in the Matrigel invasion assay. (F) Representatives of lungs excised from nude mice at 8 weeks after injection of Vec-5-8F or ZNF154-5-8F cells. Representative images of lung tumor nodules. Metastatic nodules are indicated by arrows. Representative images of H&E staining of the lung cancer tissues of mice injected with Vec-5-8F or ZNF154-5-8F cells.