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. 2017 Sep 6;8(49):85828–85837. doi: 10.18632/oncotarget.20687

Figure 5. MiRNA-29a regulated AQP1, AQP3, AQP8 in the colonic epithelial cells of IBS-D.

Figure 5

*P<0.05, **P<0.01, ***P<0.001 vs. Control. ###P<0.001 vs. IBS-D Control. Compared with the control group, the expression of AQPs decreased significantly in IBS-D control group, IBS-D +miR-29a NC group. Compared with IBS-D control group, the expression of AQPs increased significantly in IBS-D+miR-29a antagomir group. The results showed the expression of AQP1, AQP3 and AQP8 all decreased together with the increase of intestinal permeability in IBS-D rat colon which reflected that AQPs may be the key of the change of intestinal permeability.