Table 2. Association between genetic polymorphisms in the base excision repair genes and cervical cancer risk.
| Genotype | Test set | Validation set | Combined set | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases/controls | P | Adjusted OR | Cases/controls | P | Adjusted OR | Cases/controls | P | Adjusted OR | ||
| rs3213245 | TT | 462/501 | 0.0357 | 493/841 | 0.0002 | 955/1342 | <.0001 | |||
| TC | 104/140 | 0.69(0.50-0.96) | 107/293 | 0.58(0.45-0.76) | 211/433 | 0.65(0.54-0.80) | ||||
| CC | 5/16 | 0.13(0.03-0.49) | 8/31 | 0.43(0.19-0.97) | 13/47 | 0.31(0.16-0.62) | ||||
| TC/CC | 109/156 | 0.048 | 0.63(0.46-0.86) | 115/324 | <.0001 | 0.57(0.44-0.73) | 224/480 | <.0001 | 0.62(0.51-0.75) | |
| C allele | 0.0998/0.1309 | 0.1012/0.1524 | 0.1005/0.1446 | |||||||
| HWE | 0.7479/0.1039 | 0.4274/0.3695 | 0.7256/0.0922 | |||||||
| rs1052133 | GG | 196/228 | 0.3279 | 216/414 | 0.9103 | 412/642 | 0.7961 | |||
| GC | 276/335 | 1.00(0.75-1.32) | 301/568 | 1.05(0.83-1.32) | 577/903 | 1.02(0.86-1.21) | ||||
| CC | 99/94 | 1.36(0.92-1.99) | 91/183 | 0.95(0.69-1.31) | 190/277 | 1.07(0.85-1.35) | ||||
| C allele | 0.4151/0.3980 | 0.3972/0.4009 | 0.4059/0.3998 | |||||||
| HWE | 0.9135/0.1006 | 0.4042/0.6083 | 0.6119/0.1633 | |||||||
| rs1760944 | AA | 182/211 | 0.976 | 199/386 | 0.9715 | 381/597 | 0.9301 | |||
| AC | 285/324 | 1.01(0.75-1.34) | 298/564 | 1.06(0.84-1.35) | 583/888 | 1.02(0.86-1.22) | ||||
| CC | 104/122 | 1.06(0.73-1.54) | 111/215 | 1.04(0.77-1.41) | 215/337 | 1.00(0.80-1.26) | ||||
| C allele | 0.4317/0.4323 | 0.4276/0.4266 | 0.4296/0.4286 | |||||||
| HWE | 0.6805/0.9033 | 0.9757/0.7216 | 0.7579/0.8315 | |||||||
| rs1130409 | TT | 182/192 | 0.6014 | 191/350 | 0.7823 | 373/542 | 0.5295 | |||
| TG | 282/338 | 0.95(0.71-1.26) | 304/586 | 0.93(0.73-1.18) | 586/924 | 0.93(0.78-1.11) | ||||
| GG | 107/127 | 0.96(0.66-1.38) | 113/229 | 0.94(0.69-1.28) | 220/356 | 0.92(0.73-1.15) | ||||
| G allele | 0.4343/0.4505 | 0.4359/0.4481 | 0.4351/0.4490 | |||||||
| HWE | 0.9034/0.3164 | 0.6799/0.5622 | 0.7034/0.2869 | |||||||
| rs1136410 | TT | 188/192 | 0.2215 | 254/425 | 0.0898 | 442/617 | 0.087 | |||
| TC | 280/325 | 0.92(0.69-1.23) | 256/529 | 0.76(0.60-0.95) | 536/854 | 0.85(0.72-1.01) | ||||
| CC | 103/140 | 0.71(0.49-1.03) | 98/211 | 0.78(0.57-1.05) | 201/351 | 0.78(0.62-0.98) | ||||
| C allele | 0.4256/0.4604 | 0.3717/0.4082 | 0.3978/0.4270 | |||||||
| HWE | 0.9436/0.9098 | 0.0151/0.0401 | 0.0793/0.0720 | |||||||
| rs1799782 | CC | 270/287 | 0.1799 | 286/585 | 0.4467 | 556/872 | 0.685 | |||
| CT | 240/310 | 0.81(0.62-1.05) | 257/463 | 1.09(0.87-1.36) | 497/773 | 0.97(0.82-1.14) | ||||
| TT | 61/60 | 1.05(0.68-1.64) | 65/117 | 1.18(0.82-1.68) | 126/177 | 1.11(0.85-1.45) | ||||
| T allele | 0.317/0.3272 | 0.3183/0.2991 | 0.3176/0.3093 | |||||||
| HWE | 0.4835/0.0664 | 0.523/0.0748 | 0.344/0.7652 | |||||||
| rs25489 | GG | 461/526 | 0.8963 | 492/927 | 0.7778 | 953/1453 | 0.6884 | |||
| GA | 102/123 | 1.03(0.74-1.43) | 109/225 | 0.87(0.66-1.14) | 211/348 | 0.96(0.79-1.18) | ||||
| AA | 8/8 | 1.25(0.41-3.85) | 7/13 | 1.20(0.45-3.16) | 15/21 | 1.15(0.57-2.33) | ||||
| A allele | 0.1033/0.1058 | 0.1012/0.1077 | 0.1022/0.1070 | |||||||
| HWE | 0.3899/0.7893 | 0.7282/0.8742 | 0.3942/0.9746 | |||||||
| rs25487 | GG | 316/374 | 0.8493 | 333/648 | 0.7711 | 649/1022 | 0.7375 | |||
| GA | 218/243 | 1.07(0.82-1.40) | 233/429 | 1.11(0.89-1.38) | 451/672 | 1.08(0.92-1.27) | ||||
| AA | 37/40 | 0.98(0.57-1.68) | 42/88 | 0.91(0.60-1.38) | 79/128 | 0.97(0.71-1.33) | ||||
| A allele | 0.1033/0.1058 | 0.1012/0.1077 | 0.1022/0.1070 | |||||||
| HWE | 0.3899/0.7893 | 0.7282/0.8742 | 0.3942/0.9746 | |||||||
aAdjusted for age, parity, and menopausal status in the logistic regression model.