Table 2. Univariate and multivariate survival analyses of OS and CSS in patients with colorectal cancer from CMU-SO.
| Variable | Overall survival | Cancer-specific survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Gender | 0.018 | 0.003 | 0.109 | |||||
| Female | 1 | 1 | 1 | |||||
| Male | 1.270 (1.043-1.546) | 1.358 (1.113-1.657) | 1.185 (0.963-1.459) | |||||
| Age (y) | 0.144 | 0.606 | ||||||
| <60 | 1 | 1 | ||||||
| ≥60 | 1.156 (0.952-1.405) | 1.055 (0.860-1.296) | ||||||
| Tumor size (cm) | 0.717 | 0.767 | ||||||
| <4.7 | 1 | 1 | ||||||
| ≥4.7 | 1.036 (0.855-1.255) | 1.031 (0.842-1.264) | ||||||
| Tumor location | 0.319 | 0.287 | ||||||
| Colon | 1 | 1 | ||||||
| Rectum | 1.105 (0.908-1.344) | 1.120 (0.909-1.379) | ||||||
| Differentiation | <0.001 | 0.001 | <0.001 | 0.004 | ||||
| Well - moderate | 1 | 1 | 1 | 1 | ||||
| Poor - undifferentiated | 2.374 (1.816-3.104) | 1.569 (1.195-2.060) | 2.379 (1.791-3.162) | 1.523 (1.141-2.032) | ||||
| Depth of tumor | <0.001 | 0.006 | <0.001 | 0.002 | ||||
| T1 | 1 | 1 | 1 | 1 | ||||
| T2 | 3.150 (0.764-12.984) | 2.733 (0.663-11.273) | 2.519 (0.606-10.462) | 2.143 (0.516-8.909) | ||||
| T3 | 6.173 (1.532-24.868) | 3.162 (0.783-12.772) | 5.363 (1.330-21.629) | 2.677 (0.661-10.835) | ||||
| T4 | 9.321 (2.312-37.569) | 4.180 (1.033-16.911) | 8.541 (2.118-34.446) | 3.712 (0.916-15.044) | ||||
| Lymph node metastasis | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| N0 | 1 | 1 | 1 | 1 | ||||
| N1 | 4.682 (3.668-5.976) | 4.229 (3.300-5.421) | 5.434 (4.150-7.116) | 4.859 (3.695-6.390) | ||||
| N2 | 11.926 (9.122-15.592) | 10.386 (7.870-13.708) | 14.189 (10.597-19.000) | 11.834 (8.760-15.986) | ||||
| Distant metastasis | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Negative | 1 | 1 | 1 | 1 | ||||
| Positive | 4.046 (2.628-6.230) | 2.222 (1.437-3.436) | 4.316 (2.772-6.718) | 2.310 (1.476-3.615) | ||||
| TNM stage | <0.001 | <0.001 | ||||||
| I | 1 | 1 | ||||||
| II | 1.752 (1.058-2.901) | 2.241 (1.206-4.165) | ||||||
| III | 9.180 (5.772-14.599) | 13.260 (7.437-23.641) | ||||||
| IV | 17.507 (9.451-32.430) | 26.045 (12.783-53.064) | ||||||
| PLR | 0.001 | 0.002 | 0.001 | 0.003 | ||||
| <130 | 1 | 1 | 1 | 1 | ||||
| ≥130 | 1.364 (1.127-1.653) | 1.356 (1.117-1.647) | 1.409 (1.150-1.727) | 1.364 (1.111-1.675) | ||||
CI: confidence interval; CMU-SO: Department of Surgical Oncology at The First Hospital of China Medical University; HR: hazard ratio; PLR: platelet to lymphocyte ratio.