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. 2017 Sep 21;8(49):86296–86311. doi: 10.18632/oncotarget.21145

Figure 2. Tumors with a high hypoxia signature and low expression of DNA repair genes have a poor prognosis.

Figure 2

Kaplan Meier curves show the survival differences between the subgroups identified in Figure 1c, based on median expression values of the HIF2a signature and the indicated repair proteins. (a) HIF2α-BRCA1. (b) HIF2α-RAD51. (c) HIF2α-RIF1. (d) HIF2α-Ku70. (e) Tumors belonging to all 4 HIF2α-high/repair-low and to all 4 HIF2α-low/repair-high quadrants in a-d were identified by GeneVenn (www.genevenn.sourceforge.net) and analyzed separately. Tumors with high expression of the HIF2α signature and low levels of all 4 repair proteins had a very poor prognosis (green), when compared to tumors with low expression of the HIF2α signature and high expression of all 4 repair proteins (magenta).