Table 1. Cells sensitivities to JQ1 as well as basal levels of c-Myc and N-Myc expression in SCLC cell lines.
SCLC cell lines | |||||||
---|---|---|---|---|---|---|---|
High N-Myc | High c-Myc | Low c-Myc and N-Myc | |||||
H526 | H69 | H82 | DMS79 | H196 | H1963 | H446 | |
JQ1 IC50 (nM) | 236.1 | 667.1 | 1012 | 30383 | 26000 | 103755 | 8649 |
N-MYC expression | 2.35 | 1.22 | 0.67 | 0.37 | 0.49 | 0.51 | 0.51 |
C-MYC expression | 0.18 | 0.11 | 2.21 | 0.61 | 0.23 | 0.12 | 0.19 |