Table 2. Genes in which HPV was integrated in at least 5 TCGA tumors or HPV positive cell lines.

Gene name	Protein name	Number of samples with integration	Chromosome	Function	Role in cancer
KLF12	Krueppel-like factor 12	15	13	Represses AP-2 alpha gene expression	Regulates gene expression during vertebrate development and carcinogenesis
PVT1	PVT-1 oncogene	11	8	Long noncoding RNA locus identified as a candidate oncogene	Implicated in breast and ovarian cancer, AML, and Hodgkin lymphoma
POU5F1B	POU class 5 homeobox 1B	7	8	Homeobox 1 transcription factor	Induces upregulation of growth factors and promote proliferation
RAD51B	RAD51 paralog B	7	14	Homologous recombination repair pathway	Overexpression causes cell cycle G1 delay and apoptosis
MYC	c-Myc	7	8	Activates the transcription of growth-related genes	Oncogene that regulates the cancer epigenome and transcriptome
TP63	Tumor protein 63	6	3	Member of the p53 family of transcription factors	Isoforms involved in adult stem/progenitor cell regulation
ERBB2	Erb-b2 receptor tyrosine kinase 2	6	17	Binds to ligand-bound EGF receptor family members, stabilizes ligand binding, and enhances downstream signaling pathways	Amplification and/or overexpression is reported in numerous cancers, including breast and ovarian tumors