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. 2017 Sep 23;8(49):86488–86502. doi: 10.18632/oncotarget.21212

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Copyright: © 2017 Tang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) The black star represents the orthotopic xenograft tumor containing Galectin-1 overexpressing PSCs mixed with PANC-1, and the arrows represent the liver metastasis. (B) H&E staining of the orthotopic xenografts in the mice pancreas. (C) Decreased E-cadherin staining was observed in the liver metastasis. (D) Increased Vimentin staining was observed in the liver metastasis. (E) H&E staining of the liver metastases. (F) H&E staining of the stomach in mice with Galectin-1 overexpressing PSCs mixed with PANC-1. (G) Decreased E-cadherin staining was observed in the orthotopic xenografts in the mice pancreas. (H) Increased Vimentin staining was observed in the orthotopic xenografts in the mice pancreas. (I) Galectin-1 staining was observed in the liver metastasis. (J) H&E staining of the normal mice liver as a control. (K) H&E staining of the normal mice pancreas as a control. (L) The black star represents the orthotopic xenograft tumor containing wt-Galectin-1/sh-Galectin-1 PSCs mixed with PANC-1; in these cases, no liver metastasis was observed.