Table 2. Basic information of candidate SNPs in Han subjects.
| SNP_ID | Gene | Alleles A/B | Case (N) | HWE Case | Control (N) | HWE Control | OR (95% CI) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | AA | AB | BB | |||||||
| rs7571218 | EPAS1 | A/G | 8 | 32 | 30 | 1.000 | 3 | 16 | 11 | 0.413 | 0.991(0.521-1.888) | 0.979 |
| rs6743991 | A/C | 1 | 11 | 58 | 0.458 | 1 | 6 | 23 | 1.000 | 0.887(0.320-2.460) | 0.818 | |
| rs59901247 | A/C | 1 | 12 | 57 | 0.514 | 1 | 7 | 22 | 1.000 | 0.810(0.309-2.122) | 0.667 | |
| rs7567582 | T/C | 5 | 23 | 42 | 0.506 | 3 | 9 | 18 | 0.596 | 1.068(0.514-2.216) | 0.861 | |
| rs75591953 | C/T | 13 | 11 | 46 | 0.475 | 10 | 5 | 15 | 0.534 | 0.474(0.249-0.901) | 0.021 | |
| rs79843796 | C/G | 6 | 4 | 60 | 0.000 | 5 | 5 | 20 | 0.040 | 0.498(0.213-1.167) | 0.104 | |
| rs117227021 | T/G | 0 | 7 | 63 | 1.000 | 1 | 4 | 25 | 1.000 | 0.711(0.199-2.526) | 0.596 | |
| rs35508970 | C/T | 0 | 11 | 59 | 1.000 | 1 | 5 | 24 | 1.000 | 0.904(0.299-2.727) | 0.858 | |
| rs7557402 | C/G | 4 | 25 | 41 | 1.000 | 3 | 8 | 19 | 0.563 | 1.182(0.561-2.492) | 0.660 | |
| rs75984373 | C/T | 16 | 10 | 44 | 0.656 | 12 | 5 | 13 | 0.356 | 0.429(0.229-0.804) | 0.008 | |
| rs2272499 | ITGA6 | A/G | 4 | 23 | 43 | 0.729 | 1 | 12 | 17 | 0.304 | 1.09(0.515-2.308) | 0.821 |
| rs55667609 | A/G | 1 | 8 | 61 | 0.292 | 1 | 2 | 27 | 1.000 | 2.154(0.457-10.15) | 0.321 | |
| rs17676773 | G/A | 2 | 2 | 66 | 0.002 | 0 | 8 | 22 | 1.000 | 0.280(0.092-0.847) | 0.018 | |
| rs1574028 | C/A | 0 | 3 | 67 | 1.000 | 0 | 3 | 27 | 1.000 | 0.613(0.010-3.769) | 0.594 | |
| rs6716540 | T/C | 9 | 14 | 45 | 0.001 | 5 | 10 | 15 | 0.239 | 0.554(0.282-1.088) | 0.084 | |
| rs3749148 | T/G | 21 | 28 | 21 | 0.098 | 5 | 18 | 6 | 0.278 | 1.071(0.581-1.977) | 0.825 | |
| rs11895564 | G/A | 2 | 12 | 56 | 0.205 | 2 | 10 | 18 | 1.000 | 0.495(0.218-1.125) | 0.089 | |
| rs3792259 | G/C | 0 | 11 | 59 | 1.000 | 1 | 4 | 25 | 1.000 | 1.151(0.351-3.775) | 0.816 | |
| rs6744873 | G/A | 6 | 15 | 49 | 0.083 | 3 | 13 | 14 | 0.671 | 0.467(0.226-0.964) | 0.037 | |
| rs145810451 | A/G | 1 | 1 | 68 | 0.022 | 1 | 6 | 23 | 1.000 | 0.190(0.046-0.787) | 0.012 | |
| rs13002712 | ERBB4 | A/G | 19 | 35 | 16 | 1.000 | 5 | 15 | 10 | 1.000 | 1.438(0.7764-2.664) | 0.247 |
| rs6735267 | C/T | 3 | 3 | 54 | 1.000 | 3 | 3 | 24 | 1.000 | 0.460(0.090-2.355) | 0.340 | |
| rs35778743 | T/C | 0 | 1 | 69 | 1.000 | 1 | 1 | 28 | 1.000 | 0.410(0.025-6.669) | 0.518 | |
| rs934607 | A/G | 8 | 26 | 36 | 0.392 | 1 | 13 | 16 | 0.287 | 1.484(0.726-3.033) | 0.278 | |
| rs4672613 | C/T | 0 | 10 | 60 | 1.000 | 1 | 5 | 24 | 1.000 | 0.815(0.266-2.499) | 0.721 | |
| rs17335043 | A/C | 4 | 3 | 63 | 1.000 | 2 | 8 | 20 | 1.000 | 0.140(0.036-0.548) | 0.001 | |
| rs34621071 | A/G | 0 | 7 | 63 | 1.000 | 1 | 7 | 22 | 1.000 | 0.384(0.128-1.148) | 0.077 | |
| rs141267844 | A/T | 6 | 27 | 37 | 0.767 | 1 | 17 | 12 | 0.064 | 0.931(0.474-1.830) | 0.836 | |
| rs4673628 | A/G | 0 | 4 | 66 | 1.000 | 1 | 3 | 26 | 1.000 | 0.539(0.117-2.489) | 0.422 | |
| rs6710946 | T/C | 8 | 21 | 41 | 0.065 | 2 | 13 | 15 | 0.636 | 1.030(0.513-2.069) | 0.934 | |
SNP: Single-nucleotide polymorphism; OR: odds ratio; 95% CI: 95% confidence interval; HWE: Hardy-Weinberg equilibrium; Site with HWE p≤0.05 excluded; p<0.05 indicates statistical significance for allele model.