Table 3. Basic information of candidate SNPs in Tibetan subjects.
| SNP_ID | Gene | Alleles A/B | Case (N) | HWE Case | Control (N) | HWE Control | OR (95% CI) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | AA | AB | BB | |||||||
| rs7571218 | EPAS1 | G/A | 2 | 27 | 41 | 0.493 | 1 | 7 | 22 | 0.505 | 1.612(0.715-3.634) | 0.247 |
| rs6743991 | A/C | 0 | 3 | 67 | 1.000 | 0 | 0 | 30 | 1.000 | 1.354(0.253-3.726) | 0.253 | |
| rs59901247 | A/C | 2 | 7 | 61 | 0.047 | 0 | 4 | 26 | 1.000 | 1.194(0.364-3.911) | 0.770 | |
| rs7567582 | C/T | 4 | 26 | 40 | 1.000 | 1 | 9 | 20 | 1.000 | 1.429(0.669-3.054) | 0.356 | |
| rs75591953 | T/C | 3 | 8 | 59 | 0.015 | 0 | 2 | 28 | 1.000 | 3.222(0.709-14.64) | 0.111 | |
| rs79843796 | C/G | 3 | 7 | 60 | 0.001 | 4 | 0 | 26 | 0.000 | 0.464(0.172-1.247) | 0.121 | |
| rs117227021 | T/G | 1 | 1 | 68 | 0.022 | 0 | 1 | 29 | 1.000 | 1.292(0.132-12.68) | 0.826 | |
| rs35508970 | C/T | 0 | 6 | 64 | 1.000 | 0 | 2 | 28 | 1.000 | 1.299(0.255-6.625) | 0.753 | |
| rs7557402 | G/C | 7 | 26 | 37 | 0.556 | 1 | 11 | 18 | 1.000 | 1.446(0.707-2.957) | 0.311 | |
| rs75984373 | T/C | 1 | 5 | 64 | 0.146 | 0 | 1 | 29 | 1.000 | 3.105(0.374-25.81) | 0.270 | |
| rs2272499 | ITGA6 | A/G | 2 | 14 | 54 | 0.302 | 2 | 9 | 19 | 0.589 | 0.533(0.242-1.174) | 0.115 |
| rs55667609 | A/G | 0 | 4 | 66 | 1.000 | 1 | 2 | 27 | 1.000 | 0.824(0.147-4.625) | 0.825 | |
| rs17676773 | G/A | 0 | 13 | 57 | 1.000 | 0 | 6 | 24 | 1.000 | 0.921(0.333-2.551) | 0.875 | |
| rs1574028 | C/A | 0 | 7 | 63 | 1.000 | 0 | 3 | 27 | 1.000 | 1.000(0.250-4.005) | 1.000 | |
| rs6716540 | T/C | 6 | 30 | 34 | 0.318 | 5 | 15 | 10 | 1.000 | 0.571(0.289-1.128) | 0.105 | |
| rs3749148 | G/T | 14 | 30 | 26 | 0.455 | 10 | 14 | 16 | 1.000 | 0.522(0.283-0.964) | 0.037 | |
| rs11895564 | G/A | 1 | 17 | 52 | 1.000 | 0 | 11 | 19 | 0.551 | 0.700(0.310-1.578) | 0.387 | |
| rs3792259 | G/C | 1 | 3 | 66 | 1.000 | 0 | 3 | 27 | 1.000 | 0.422(0.083-2.155) | 0.286 | |
| rs6744873 | G/A | 3 | 27 | 40 | 0.072 | 3 | 14 | 13 | 1.000 | 0.651(0.320-1.321) | 0.233 | |
| rs145810451 | A/G | 0 | 7 | 63 | 1.000 | 0 | 2 | 28 | 1.000 | 1.55(0.3124-7.687) | 0.589 | |
| rs13002712 | ERBB4 | A/G | 14 | 41 | 15 | 0.231 | 4 | 16 | 10 | 0.711 | 1.458(0.789-2.693) | 0.228 |
| rs6735267 | C/T | 8 | 13 | 49 | 1.000 | 3 | 3 | 24 | 1.000 | 1.464(0.638-2.573) | 0.130 | |
| rs35778743 | T/C | 0 | 9 | 61 | 1.000 | 0 | 5 | 25 | 1.000 | 0.756(0.242-2.357) | 0.629 | |
| rs934607 | A/G | 2 | 29 | 39 | 0.324 | 4 | 17 | 9 | 0.472 | 0.432(0.227-0.823) | 0.010 | |
| rs4672613 | C/T | 1 | 10 | 59 | 0.402 | 0 | 4 | 26 | 1.000 | 1.312(0.406-4.247) | 0.649 | |
| rs17335043 | A/C | 3 | 5 | 62 | 1.000 | 1 | 5 | 24 | 1.000 | 0.411(0.114-1.478) | 0.162 | |
| rs34621071 | A/G | 0 | 8 | 62 | 1.000 | 0 | 2 | 28 | 1.000 | 1.758(0.362-8.533) | 0.479 | |
| rs141267844 | A/T | 3 | 24 | 43 | 1.000 | 4 | 15 | 11 | 1.000 | 0.439(0.227-0.848) | 0.013 | |
| rs4673628 | A/G | 0 | 2 | 68 | 1.000 | 0 | 3 | 27 | 1.000 | 0.275(0.045-1.692) | 0.138 | |
| rs6710946 | T/C | 2 | 26 | 42 | 0.720 | 0 | 3 | 27 | 1.000 | 5.182(1.516-17.71) | 0.004 | |
SNP: Single-nucleotide polymorphism; OR: odds ratio; 95% CI: 95% confidence interval; HWE: Hardy-Weinberg equilibrium; Site with HWE p≤0.05 excluded; p<0.05 indicates statistical significance for allele model.