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. 2017 Mar 28;6(6):1465–1476. doi: 10.1002/sctm.16-0128

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Generation of glutamatergic neurons. (A): Low (left) and high (right) magnification images of cell cultures 20 days after induced pluripotent stem cells (iPSCs) differentiation into glutamatergic neurons. Immunofluorescence staining was performed using antibodies against TUJ1, TBR1, and glutamate, scale bar = 50 µm. (B): Whole‐cell patch‐clamp recordings obtained from the cell soma made in current‐clamp mode. The top set of traces are representative action potentials from neurons derived from euploid iPSCs. The middle set of traces are representative recordings of from neurons that were generated from T21 iPSCs. Stimulus protocol (current steps) is shown at the bottom.