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. 2017 Jun 8;6(7):1644–1659. doi: 10.1002/sctm.16-0222

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© 2017 The Authors stemcellstranslationalmedicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Micro‐CT reconstructions of defect regions after 4 and 8 weeks post‐implantation and micro‐CT scoring for bony bridging and union within defects. (A): Three‐dimensional reconstructed micro‐CT images (top) and Tb.Th maps (bottom) of the defect region in representative samples for each time point. Tb.Th increased from blue to green to red. White scale bar = 500 μm. All images are at the same scale. (B): Scoring guide for extent of bony bridging and union using micro‐CT reconstructions (adapted from Patel et al. 47). (C): Scores for bony bridging and union for the five in vivo groups examined at 4 and 8 weeks. Groups that do not share a letter are significantly different at p < .05. Abbreviations: micro‐CT, micro‐computed tomography; Tb.Th, trabecular thickness.