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. 2017 Jul 5;6(9):1795–1802. doi: 10.1002/sctm.16-0458

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Basal tone changes in rabbits: Rabbits in the non‐treated group (red bars, n = 6) showed a significant sustained decrease (p < .05) in basal tone at 1 and 3 months following sphincterectomy compared with pre‐sphincterectomy. Rabbits in the treated group (blue bars) showed restoration of basal tone at 1 and 3 months following implantation of biosphincters. Basal tone at 3 months post‐sphincterectomy was significantly lower than basal tone in rabbits at 3 months post implant (p < .05). Rabbits in sham group (green bars) showed no significant difference (p > .05) in basal tone compared with the non‐treated group (red bars) but was significantly lower than basal tone in the treated group (blue bars) at 1‐ and 3‐month time point following sham surgery (p < .05).