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. 2017 Feb 15;6(6):1547–1556. doi: 10.1002/sctm.16-0198

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Neurons derived from human induced pluripotent stem cells exhibit properties of synaptic integration in vivo. (A): Representative traces from neurons in voltage clamp at each time point demonstrating sEPSCs at 26 and 50 weeks. (B): Accompanying graphs show the frequency (Hz) and amplitude (pA) of sEPSCs in recorded cells at each time‐point, as well as the proportion of cells exhibiting sEPSCs (*, p < .05 vs. 10 week, #, p < .05 vs. 26 week, one way ANOVA or z test). Abbreviations: EPSCs, excitatory postsynaptic currents; sEPSCs, spontaneous excitatory postsynaptic currents.