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editorial

. 2017 Jul 6;6(8):1661–1665. doi: 10.1002/sctm.16-0490

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Shared surface receptors and signaling in HSCs, Mgk‐biased HSCs, and committed Mgks. In the immunophenotypic HSC compartment (mainly the CD41⁺ subpopulation), Mgk‐biased HSCs exist. HSCs, Mgk‐biased HSCs, and MKPs share several surface molecules. Transcripts of Mgk‐related genes, such as Vwf or CD42b, can be detected in Mgk‐biased HSCs, but protein synthesis is inhibited in the steady state. External signaling such as inflammatory cytokine or TPO/Mpl signaling can trigger protein synthesis, induce Mgk lineage differentiation, and generate adequate numbers of platelets during emergency thrombocytosis. Abbreviations: HSC, hematopoietic stem cell; Mgk, megakaryocyte; MKP, Mgk progenitor; TPO, thrombopoietin.