Fig 8. Roles of initial [Ca²⁺]_i, I_K1 density, and g_gap in DAD variability in the fiber model.

(a) Spatiotemporal profile of V (left) and V_max profile (right) in a 480-cell fiber under baseline conditions. Similar simulations are shown with 50% I_K1 reduction (b) and both 50% I_K1 and 50% g_gap (c). The range of V_max values are indicated for the red traces, which correspond to the images on the left. To avoid boundary effects, the outer 24 cells on either end were initialized to normal SR loads. The inner cells were initialized to identical initial conditions to those of Fig 6. All simulations initialized with [Na⁺]_i = 10 mM.