Figure 2.

MEAN inhibited HepG2-luc xenograft tumor growth more effectively than sorafenib under same treatment conditions in mice. Starting at d 11 after inoculation of tumor cells s.c., mice were treated with MEAN (15 mg/kg), sorafenib (15 mg/kg), or MEAN and sorafenib in combination at 15 mg/kg each, or vehicle through i.p. administration at schedule of 5 d on and 2 d off for 42 d. Tumor growth was measured by whole-mount imaging of luciferin florescence (representative images) (A), photon counts twice a week (B), or photon count at end of experiment, d 42 (C), by volume (D), and by tumor weight at d 42 (E). *P < 0.5, **P < 0.01 (Student’s t test). Lack of black bar indicates P > 0.5 (n = 5).