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Toxicity induced by treatment of MEAN, sorafenib, or combination of both was measured against vehicle-treated group through monitoring body weight changes throughout treatment course (A) and detecting serum levels of liver enzymes at experimental end point (B). Liver enzymes were recovered 2 wk after experimental end point (d 42) (C). *P < 0.5, **P < 0.01 (Student’s t test). Lack of black bar indicates P > 0.5 (n = 5).
