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. 2017 Nov 16;12(11):e0188121. doi: 10.1371/journal.pone.0188121

Table 1. List of top 20 genes identified from siRNA library screening.

Gene symbol Gene description Percentage of caspase 3 activity (compare to siNTC) S.D. p-value
1 TNFSF12 Tumor necrosis factor ligand superfamily member 12 44.25% 6.95 0.0002
2 RIPK2 Receptor-interacting serine/threonine protein kinase 2 45.02% 13.36 0.0022
3 STK17A Serine/threonine kinase 17a 47.46% 7.58 0.0003
4 CARD14 Caspase recruitment domain family member 14 48.12% 6.05 0.0001
5 PDCD2 Programmed cell death-2 48.51% 4.56 < 0.0001
6 HDAC3 Histone deacetylase 3 48.82% 7.15 0.0003
7 PSEN2 Presenilin 2 48.99% 6.86 0.0002
8 PIM1 Serine/threonine-protein kinase Pim-1 51.28% 17.36 0.0374
9 SST Somatostatin 52.20% 14.23 0.0047
10 RAD21 RAD21 homolog (S. pombe) 53.45% 11.91 0.0027
11 SPHK2 Sphingosine kinase 2 54.68% 16.96 0.0107
12 RASA1 RAS P21 protein activator (GTPase activating protein) 1 54.71% 1.79 < 0.0001
13 NME3 NME/NM23 nucleoside diphosphate kinase 3 54.96% 8.82 0.0010
14 CASP3 Caspase 3, apoptosis-related cysteine peptidase 55.20% 8.89 0.0009
15 CYCS Cytochrome C 55.76% 7.28 0.0005
16 NME5 NME/NM23 nucleoside diphosphate kinase 5 56.02% 8.31 0.0008
17 CARD11 Caspase recruitment domain family member 11 56.23% 2.63 < 0.0001
18 STK17B Serine/threonine kinase 17b 57.00% 9.32 0.0014
19 SIVA1 SIVA1, Apoptosis-Inducing Factor 57.09% 8.50 0.0010
20 CTNNAL1 Catenin alpha-like protein 57.13% 8.03 0.0008