Table 5. Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility: Fecundability Ratio (FR) (95% Confidence Intervals) for each PFC.
| Cycle-specific model1 | Day-specific model2 | ||||
|---|---|---|---|---|---|
| Unadjusted FR | Adjusted FR3 | Fully adjusted FR4 | Unadjusted FR | Adjusted FR3 | |
| PFOA | 1.20 (0.69,2.10) | 1.16 (0.69,2.02) | 1.15 (0.66,2.01) | 0.95 (0.25,2.08) | 0.96 (0.31,1.94) |
| PFOS | 0.91 (0.51,1.63) | 0.87 (0.49,1.56) | 0.89 (0.49,1.60) | 1.03 (0.30,2.45) | 0.99 (0.28,2.32) |
| PFNA | 0.78 (0.43,1.42) | 0.80 (0.43,1.45) | 0.84 (0.46,1.54) | 0.91 (0.23,1.66) | 0.98 (0.32,2.10) |
| PFHxS | 1.46 (0.84,2.55) | 1.42 (0.81,2.47) | 1.40 (0.79,2.49) | 0.95 (0.31,1.71) | 0.96 (0.31,1.71) |
| sum PFC | 0.78 (0.44,1.41) | 0.74 (0.41,1.33) | 0.67 (0.36,1.26) | 1.01 (0.32,2.17) | 1.05 (0.35,2.51) |
upper quartile of each PFC considered exposed
PFOA, perfluorooctanoate; PFOS, perfluorooctane sulfonate; PFNA, perfluorononanoic acid; PFHxS, perfluorohexanesulfonic acid; PFC, perfluorinated chemicals
1
Model 1: based on a Cox proportional hazards model
2
Model 2: based on a day-specific probability model
3
adjusted for age
4
adjusted for age and mean cycle length