Table 7. White matter microstructure measures in unmedicated and medicated participants with hypertension after propensity score matching.
| Unmedicated | Medicated | p value | |
|---|---|---|---|
| N | 834 | 834 | |
| White matter microstructure measure | |||
| FA | 0.028±0.619 | –0.102±0.691 | 0.002 |
| MD | 0.052±0.651 | 0.191±0.708 | 0.001 |
| MO | 0.013±0.352 | –0.003±0.344 | 1.000 |
| ICVF | –0.008±0.826 | –0.116±0.875 | 0.123 |
| OD | –0.059±0.501 | –0.055±0.507 | 1.000 |
| ISOVF | 0.059±0.550 | 0.170±0.595 | 0.002 |
| Brain volume measure | |||
| Total brain volume (ml) | 1496.2±68.8 | 1492.1±69.2 | 0.806 |
| Grey matter volume (ml) | 788.8±43.8 | 784.8±43.6 | 0.267 |
| White matter volume (ml) | 707.4±40.2 | 707.3±41.3 | 1.000 |
Variables were expressed as means ± standard deviations and were analyzed using the Student’s t-test. White matter microstructural measures are expressed as mean z-scores referenced to the total study population (n = 4659). Significance levels were set at p<0.05 after Bonferroni correction. Abbreviations: FA, Fractional anisotropy; ICVF, Intracellular volume fraction; ISOVF, Isotropic volume fraction; MD, Mean diffusivity; MO, Diffusion tensor mode; OD, Orientation dispersion.