Fig 6. BK channels shape the action potential afterhyperpolarization.
(Top) Representative traces of 1st action potential comparing BK channel block (paxilline, grey trace) in control (A) and pilocarpine treated (B) granule cells. (C) Average fAHP amplitude before and after paxilline from control and seizure experienced animals. (D) The relative effect of paxilline on fAHP amplitude. (E) Average 10% width of first action potential before and after paxilline from control and seizure experienced animals. (F) The relative effect of paxilline on the 10% width of the first action potential. (Control n = 9, seizure n = 8).