Fig 7. Seizures do not change BK channel contribution to early spike frequency.
(Top) Representative traces of first 20 ms of voltage response to a 200 pA constant current injection. The voltages traces are aligned at the first spike (pre-spike tracings are not shown) to display effects on instantaneous frequency. Before (black trace) and after BK channel block (paxilline, grey traces) in control (A) and pilocarpine treated (B) granule cells. (C) Average instantaneous firing frequency of 1st action potential before and after paxilline from control and seizure experienced animals. (D) Average change in instantaneous firing frequency resulting from blocking BK channels in control and pilocarpine treated mice. (Control n = 9, seizure n = 8).