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. 2017 Nov 16;12(11):e0188064. doi: 10.1371/journal.pone.0188064

Fig 9. Reduced β4 expression has consequences on seizure threshold.

Fig 9

(A) EEG recordings of mice monitored for 24 hours for spontaneous EEG activity (top panels) and in response to cumulative increased doses of kainic acid (KA, 10 mg/Kg) at 30 minute intervals (bottom panels). Wild type β4+/+ do not have spontaneous seizures. One heterozygous β4-/+ had a spontaneous focal seizure (above) and had generalized seizures (bottom) within 10 minutes of a single dose (10 mg/Kg) of KA. β4+/+ control mice required a second dose of kainic acid (20 mg/Kg total) to demonstrate seizures (bottom left). Time scale is 1 second per division. The channels recorded were from left temporal (top channel), right frontal (middle channel), and right temporal (bottom channel). B. Average time to 1st seizure and C. total seizure time after KA in β4+/+ and β4+/- mice (N = 7 each β4+/+ and β4+/-).