Table 1. Demographic, clinical and virological characteristics of individual patients.
Case | Blood Type | Age | Etiology | Hepatitis B history (years) |
MELD | Pre-LT | At the start of vaccination | Anti-HBs titer (IU/L) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HBsAg | Anti-HBs | HBV-DNA | Interval from LT (days) | BMI | Immuno- suppression |
NAs | Before vaccine | End of vaccine | Last f/u | ||||||
1 | O | 55 | HCC+BLC | 23 | 10 | +* | -* | 2.28*104 | 514 | 27.68 | TC+SR | ETV | 53.76 | 29.78 | 26.58 |
2 | O | 40 | BLC | 4 | 19 | 0.02 | 0 | 2.6*103 | 1607 | 23.51 | SR | ETV | 1.04 | 52.38 | 72.77 |
3 | A | 48 | B-FHF | 1 | NA | + | - | NA | 1441 | 29.27 | TC | ADV | 31.11 | 26.19 | 24.13 |
4 | B | 43 | BLC | 23 | 3 | 250 | 0 | 6.07*105 | 686 | 21.22 | TC+MMF | ADV | 45.84 | 57.13 | 50.19 |
5 | A | 53 | HCC+BLC | 23 | 8 | 250 | 1.52 | NA | 563 | 21.80 | TC+MMF | ETV | 4.87 | 17.18 | 16.64 |
6 | A | 26 | B-FHF | 3 | 23 | 0.21 | 29.3 | 8.64*102 | 482 | 26.30 | TC+MMF | ETV | 7.70 | 4.98 | 9.05 |
7 | O | 53 | HCC+BLC | 23 | 24 | + | - | 9.75*106 | 3218 | 21.94 | TC | LAM | 19.87 | 73.04 | 53.95 |
8 | A | 34 | BLC | 13 | 14 | 0.39 | 0 | NA | 1750 | 24.22 | TC | LAM | 48.40 | 13.56 | 7.81 |
9 | O | 59 | BLC | 13 | 21 | 1.07 | 0 | NA | 2756 | 19.10 | TC+MMF | LAM | 30.96 | 46.31 | 23.05 |
10 | A | 64 | HCC+BLC | 1 | 4 | 1.23 | 0 | <100 | 921 | 27.22 | TC+MMF | ADV | 4.89 | 1.89 | 2.69 |
11 | O | 37 | BLC | 14 | 24 | + | - | <100 | 4894 | 21.97 | CyA | LAM | 10.63 | 10.6 | 13.17 |
12 | O | 46 | HCC+BLC | 23 | 6 | + | - | 3.38*103 | 608 | 27.36 | SR | ETV | 15.38 | 45.48 | 53.16 |
13 | O | 48 | HCC+BLC | 6 | 22 | 18.21 | 0 | NA | 726 | 29.41 | TC+MMF | LAM | 26.08 | 33.48 | 44.79 |
14 | A | 59 | HCC | 3 | 14 | 250 | 0 | 9.57*103 | 610 | 22.41 | TC+MMF | ADV | 0.10 | 167.51 | 113.51 |
15 | B | 44 | BLC | 8 | 22 | 0.02 | 0 | NA | 1307 | 20.55 | TC+MMF | ETV | 9.13 | 13.77 | 36.17 |
16 | O | 36 | BLC | 5 | 19 | 250 | 0 | 1.96*103 | 633 | 22.65 | TC+MMF | ADV | 30.70 | 26.94 | 33.25 |
17 | A | 62 | HCC+BLC | 20 | 19 | 0.01 | 0 | 2.18*107 | 390 | 20.90 | SR+CyA | ETV | 21.62 | 16.91 | 21.62 |
18 | A | 60 | BLC | 10 | 11 | 250 | 0 | <100 | 790 | 24.44 | TC+MMF | ETV | 32.59 | 30.5 | 56.49 |
19 | B | 38 | HCC | 3 | 8 | 250 | 0.09 | <100 | 941 | 22.66 | TC+MMF | ETV | 0.00 | 11.95 | 0.35 |
20 | O | 42 | BLC | 13 | NA | 0.02 | 0.35 | NA | 1575 | 23.81 | TC+MMF | LAM | 13.98 | 10.46 | 10.57 |
21 | O | 37 | B-FHF | 13 | 25 | 250 | 0 | NA | 1532 | 19.84 | TC+MMF | ETV | 15.04 | 19.18 | 27.67 |
22 | B | 61 | BLC | 1 | 10 | 90.28 | 14.37 | 3.35*103 | 945 | 26.89 | SR | ETV | 14.14 | 15.45 | 9.74 |
23 | O | 57 | BLC | 5 | 14 | 250 | 0.21 | 6.95*106 | 394 | 24.80 | TC+MMF | ETV | 36.87 | 19.58 | 7.536 |
24 | A | 42 | HCC | 7 | 3 | 250 | 0.42 | 1.39*103 | 972 | 19.96 | TC+MMF | LAM | 15.36 | 14.55 | 14.55 |
25 | B | 47 | HCC+BLC | 10 | 7 | 250 | 0.26 | <100 | 397 | 26.30 | TC+MMF | ETV | 17.86 | 15.83 | 11.76 |
26 | B | 39 | B-FHF | 7 | 26 | 250 | 0.51 | 7.14*107 | 501 | 26.17 | TC+MMF | ETV | 26.12 | 28.38 | 12.85 |
27 | AB | 56 | HCC+BLC | 33 | 14 | 114.16 | 1.42 | NA | 1853 | 24.22 | TC | ADV | 2.43 | 0.68 | 0.68 |
*, results of qualitative detection from primary hospital.
B-FHF, hepatitis B related fulminant hepatic failure; BLC, hepatitis B related liver cirrhosis; HCC, hepatocellular carcinoma; NAs, nucleos(t)ide analogues; LAM, lamivudine; ADV, adefovir dipivoxyl; ETV, entecavir; TC, tacrolimus; SR, sirolimus; MMF, mycophenolate mofetil; CyA, cyclosporine A; f/u, follow-up; NA, not applicable.