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. 2017 Nov 16;12(11):e0187333. doi: 10.1371/journal.pone.0187333

Fig 1. B-1 lymphocytes, but not other peritoneal cells, induce the pro-metastatic effect on B16F10 melanoma cells.

Fig 1

A) Adherent peritoneal cells (apc) from wild-type mice, but not from B cell-deficient mice (BKO), obtained from enriched peritoneal cell cultures increases B16F10 metastatic potential upon cell-to-cell contact. B) The same results were obtained with cell-sorting technique, confirming that B-1 lymphocytes are responsible for changes in the melanoma behavior. (Bars represent the mean number of lung tumor per experimental condition ±SD (n = 4); **p < 0.01; ***p < 0.001, using one-way ANOVA with Tukey’s post hoc test.