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. 2017 Nov 16;12(11):e0187333. doi: 10.1371/journal.pone.0187333

Fig 3. IL-10 deficiency is associated with impaired expression of claudin-10 in B-1 lymphocytes.

Fig 3

Total RNA of B-1 lymphocytes enriched culture from wild-type (B-1WT) or IL-10-/- knockout (B-1IL-10-/-) mice was submitted to microarray analysis. A) Heatmap showing differential expression of eleven transcripts between B-1WT and B-1IL-10-/- lymphocytes, and the down-regulation of claudin-10 (cldn-10) in B-1IL-10-/- samples. B) Western blot analysis of cldn-10 protein in whole-cell extracts from B-1WT and B-1IL-10-/-. β-actin protein was used as internal control.