Table 1. Association of mouse knockout phenotypes with rare variants in CNR1 and DAGLA.
| Gene* | Phenotype | Cases | Controls | OR | P-value |
|---|---|---|---|---|---|
| CNR1 | Pain sensitivity | 9/22 | 156/950 | 3.5 | 0.036 |
| CNR1 | Anxiety | 7/22 | 122/950 | 3.2 | 0.131 |
| CNR1 | Memory disorder | 3/22 | 1/950 | 150 | 0.0003 |
| CNR1 | Sleep disorder | 6/22 | 33/950 | 10.4 | 0.001 |
| CNR1 | Urinary frequency | 2/22 | 19/950 | 4.9 | 0.301 |
| CNR1 | Seizures | 11/22 | 402/950 | 1.4 | 1.000 |
| CNR1 | Hearing loss | 1/22 | 31/950 | 1.4 | 1.000 |
| CNR1 | Pain sensitivity and anxiety | 5/22 | 47/950 | 5.7 | 0.030 |
| CNR1 | Sleep disorder and anxiety | 4/22 | 8/950 | 26.2 | 0.001 |
| CNR1 | Pain sensitivity and memory disorder | 3/22 | 1/950 | 150 | 0.000 |
| CNR1 | Pain sensitivity, memory and sleep disorder | 3/22 | 1/950 | 150 | 0.000 |
| CNR1 | Pain sensitivity, anxiety and memory disorder | 2/22 | 0/950 | N/A | 0.003 |
| CNR1 | Pain sensitivity, anxiety, memory and sleep disorder | 2/22 | 0/950 | N/A | 0.003 |
| CNR1 | Pain sensitivity and sleep disorder | 3/22 | 7/950 | 21.3 | 0.005 |
| DAGLA | Anxiety | 2/35 | 177/950 | 0.26 | 0.211 |
| DAGLA | Neurodevelopmental disorder | 27/35 | 448/950 | 3.78 | 0.001 |
| DAGLA | Anxiety and neurodevelopmental disorder | 2/35 | 98/950 | 0.53 | 1.000 |
| DAGLA | Seizures | 30/35 | 595/950 | 3.84 | 0.032 |
| DAGLA | Seizures and neurodevelopmental disorder | 22/35 | 332/950 | 3.15 | 0.003 |
*For each gene, the phenotypes that were evaluated are listed along with the number of cases or controls in which that phenotype was present out of the total number. Also listed are the odds ratio (OR), and P-values corrected for multiple testing. Confidence intervals for the odds ratios are provided in an extended version of the table in the supporting information (S7 Table).