Fig 3. Competition for CaM alters binding dynamics.

Time-course of CaM binding partners bound to various states of CaM for 1 second of 10 Hz Ca²⁺ flux: CaM₀ (blue), CaM_2N (red), CaM_2C (green), CaM₄ (purple), and CaM_tot (orange). CaM_tot is the sum of all CaM-bound states for a given protein. The concentration of each species is normalized against its maximum value of CaM_tot. Solid lines denote the isolated model. Dotted lines denote the competitive model. The differences between isolated and competitive behavior are more significant for some CaM binding partners than others.