Fig 4. Competition tunes activation frequencies.

(A) and (B) show normalized activation of CaM as a function of frequency for the isolated and competitive models, respectively. Red denotes peak activation; blue denotes minimal activation. Frequency windows of peak activation tend to narrow and shift for many of the binding partners in the competitive case. Indeed, (C) indicates a sharpening of activation frequency windows as an increase in specificity in the competitive model, at least for most proteins. Specificity is S_b multiplied by 100 percent.