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. 2017 Nov 6;13(11):e1005827. doi: 10.1371/journal.pcbi.1005827

Fig 3. Benchmark of single-sequence prediction of non-canonical base pairs.

Fig 3

(A) Prediction accuracy of the lowest free energy structure, evaluated on non-canonical pairs. This includes a calculation where CycleFold is constrained to include the known canonical base pairs to illustrate the performance of the NCM approach when canonical base pairs are known. (B) Prediction with CycleFold, using structures composed of highly probable non-canonical pairs. Sensitivity and PPV are reported for structures with probability greater than a specified threshold (labeled on the plot). This demonstrates that the threshold stringency provides a tradeoff in terms of sensitivity and PPV.