Table 1.
The antibacterial activity of compounds 1–9.
| Cpd | MIC (µg/mL)
|
HC50(µg/mL) | AI[b] | |||||
|---|---|---|---|---|---|---|---|---|
| Gram Positive | Gram Negative | |||||||
|
| ||||||||
| MRSA | MRSE | VRE | E. Coli | PA | KP | |||
| 1 | >25 | ND[a] | ND | >25 | ND | ND | ND | ND |
| 2 | >25 | ND | ND | >25 | ND | ND | ND | ND |
| 3 | 12 | >25 | >25 | 1.5 | >25 | >25 | ND | ND |
| 4 | 12 | >25 | >25 | 3.0 | >25 | >25 | ND | ND |
| 5 | 0.33 | 0.75 | 0.75 | 1.5 | 12 | 3.0 | 140 | 424 |
| 6 | 3.0 | 1.5 | 1.5 | 3.0 | 25 | 3.0 | >250 | >83 |
| 7 | 0.33 | 0.75 | 0.75 | 1.5 | 6.0 | 1.5 | >250 | >769 |
| 8 | 0.16 | 0.75 | 0.75 | 0.75 | 4.0 | 0.75 | >250 | >1534 |
| 9 | >25 | ND | ND | 3.0 | ND | ND | ND | ND |
| D[c] | 0.5 | 0.5 | 1.0 | >25 | >25 | >25 | ||
| C[d] | >25 | >25 | >25 | 0.5 | 1.0 | 0.5 | ||
[a]
ND, Not determined because compounds are not active.
[b]
AI, Activity Index, determined by HC50/MICMRSA.
[c]
D, Daptomycin, is included for comparison against gram-(+) bacteria.
[d]
C, Colistin, was included in the test as the positive control against gram-(−) bacteria.