Table 1.
Genotypes of samples at various developmental stages.
| Genotype | Observed (Expected)
|
||||
|---|---|---|---|---|---|
| P21 | P0 | E11.5 | E10.5 | E9.5 | |
| Hdac1F/+, Hdac2F/+ | 4 (5) | 13 (8) | 3 (4.625) | 7 (5.875) | 8 (8.75) |
| Hdac1F/+, Hdac2F/F | 7 (5) | 7 (8) | 3 (4.625) | 7 (5.875) | 8 (8.75) |
| Hdac1F/F, Hdac2F/+ | 10 (5) | 15 (8) | 1 (4.625) | 3 (5.875) | 5 (8.75) |
| Hdac1F/F, Hdac2F/F | 8 (5) | 10 (8) | 13 (4.625) | 5 (5.875) | 14 (8.75) |
| Wnt1-Cre2; Hdac1F/+, Hdac2F/+ | 11 (5) | 9 (8) | 6 (4.625) | 4 (5.875) | 10 (8.75) |
| Wnt1-Cre2; Hdac1F/+, Hdac2F/F | 0 (5) | 6a,b (8) | 4 (4.625) | 7 (5.875) | 13 (8.75) |
| Wnt1-Cre2; Hdac1F/F, Hdac2F/+ | 0 (5) | 4c,d (8) | 2 (4.625) | 5 (5.875) | 5 (8.75) |
| Wnt1-Cre2; Hdac1F/F, Hdac2F/F | 0 (5) | 0 (8) | 5e (4.625) | 9 (5.875) | 7 (8.75) |
|
| |||||
| Total (p value): | 40 (p<0.001) | 51 (p=0.004) | 37 (p=0.003) | 42 (p=0.71) | 70 (p=0.25) |
Wnt1-Cre2; Hdac1F/+; Hdac1F/+ mice were crossed with Hdac1F/F; Hdac2F/F mice and samples were collected at the designated time point.
a
2 pups found cyanotic with distended abdomen/pulmonary distress.
b
3 pups recovered dead.
c
2 pups recovered dead.
d
1 pup found cyanotic in pulmonary distress.
e
5 embryos found reabsorbing with hemorrhage.