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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Cancer Res. 2017 Sep 18;77(22):6453–6461. doi: 10.1158/0008-5472.CAN-16-3279

Figure 1.

Figure 1

Tumor cell invasion in tissue-engineered microvessels. A, illustration of 3D microvessel and the resulting 2D projected image from widefield microscopy focused in the middle/equator of the vessel. B, single dual-labeled MDA-MB-231 breast cancer cell (BCC) extends multiple protrusions into the ECM-vessel interface over 6 hours, which coalesce into a larger protrusion at the interface over 12 hours. C, multiple BCCs invading into the ECM-vessel interface using amoeboid motility, as shown by the nuclear deformation observed at 2.67 hours. Flow is from left to right.