Table 1.

Transcription factors implicated during lacrimal gland development and maintenance.

Genes	Functional relevance during Lacrimal gland development
	Mice	Phenotype in humans
Pax6	Budding, competence factor	Not reported
Pax1	Not studied	Lacrimal duct stenosis
Eya1	Not studied	Lacrimal gland aplasia, duct stenosis
Six1	Branching morphogenesis	Lacrimal duct stenosis
Otx1	Budding	Not reported
p63	Budding	Lacrimal-duct atresia, obstructed lacrimal puncta
Runx1–3	Branching morphogenesis	Not reported
Klf5	Preservation of glandular function during post-natal stages	Not reported
Sox10	Growth and branching morphogenesis	Hypo-plastic or no lacrimal gland
Ap2α	Not studied	Lacrimal duct obstruction