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Link N and fullerol increased collagen II and aggrecan expression in 3D culture for 14 days. Cells were treated with or without IL-1α with addition of LN, fullerol, or LN + fullerol. The cell pellets were harvested for RNA isolation and the gene expression of collagen II and aggrecan was measured with real-time reverse transcriptionPCR. *p < 0.05 versus control; #p < 0.05 versus IL-1α-treated group.
