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Mechanism of effectiveness of PRRT. After the somatostatin (SS) analog linked to the isotope binds to the membrane somatostatin receptor, the radiopeptide/somatostatin receptor complex is internalized. Thus, radioactivity is transported into the intracellular receptor recycling compartment of the NET cell where it exerts its action in proximity to the nucleus. PRRT, peptide receptor radionuclide therapy.
