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. 2017 Nov 16;7:15738. doi: 10.1038/s41598-017-15992-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results of a pilot study to assess the safety of Maraba virus in cats. Six healthy purpose-bred research cats were vaccinated intramuscularly with 1 × 10¹⁰ pfu of an E1/E3-deleted replication-deficient recombinant human serotype 5 adenovirus (Ad) expressing the melanoma-associated antigen human dopachrome tautomerase (hDCT) on day 0. On day 21 cats were boosted by intravenous infusion of 2 × 10⁹ (cats #H6 and H7), 2 × 10¹⁰ (cats #I5 and D4) or 2 × 10¹¹ (cats #E6 and E7) pfu of a replication-competent Maraba virus (MG1) expressing hDCT. (a) Rectal temperatures and (b) weights were monitored. (c) Urine and plasma samples acquired on day 23 of the study (i.e. two days post-boost) were assessed for the presence of Maraba virus genomes by quantitative RT-PCR. Data values for each individual cat are shown.