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. 2017 Nov 16;7:15738. doi: 10.1038/s41598-017-15992-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-mortem lesions of unknown etiology from cats treated with Maraba virus. Five healthy purpose-bred research cats were vaccinated intramuscularly with 1 × 10¹⁰ pfu of an E1/E3-deleted replication-deficient recombinant human serotype 5 adenovirus expressing the tumour-associated antigen human placenta specific 1 (hPLAC1) on day 0. On day 21 cats were boosted by intravenous infusion of 2.5 × 10¹¹ pfu of a replication-competent Maraba virus expressing hPLAC1. On day 39 (i.e. 18 days post-boost), cats were euthanized for post-mortem analysis by a board-certified veterinary pathologist. (a) One cat had evidence of focal coronary arteropathy consisting of a partially thickened arterial wall (arrow). (b) One other cat had mild renal pyelitis with subepithelial infiltration of neutrophils (arrow, upper left panel), focal myocardial fibrosis (arrow, upper right panel), pulmonary congestion (lower left panel) and mild cholangitis (arrow lower right panel).