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. 2017 Nov 17;8:1577. doi: 10.1038/s41467-017-01746-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Coordination of the rigid-body rotation of domain II. The D, B-like and B states were shown schematically and in structural detail with the focus on domain II (red), the EtfB arm and anchor (green), the EtfB protrusion (brown) and the EtfA hairpin (orange). The postulated signal transmission over 30–40 Å induced by NADH binding or NAD⁺ release represents the first attempt to understand the coordination of the shuttling process between the B and D states