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. 2017 Nov 16;7:15753. doi: 10.1038/s41598-017-16016-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The photoacoustic imaging and corresponding signal intensity of (A) UCNP@mSiO₂-ICG and (B) pure ICG under 800 nm laser with irradiation time at 0 min and 15 min. Note that the absorbance is normalized in 800 nm. (C) Mice brain imaging after injection of UCNP@mSiO₂-ICG and pure ICG. The excitation wavelength is 800 nm with pulsed and continuous laer, n=3. SSS, superior sagittal sinus. (D) The in vivo photoacoustic intensity verusus the intravenous injection time.