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. 2017 Nov 16;7:15752. doi: 10.1038/s41598-017-15793-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic of experimental implementation of the 22q11.2 DS model. (a) Single-embryo primary cell culture preparation of hippocampal neurons from WT, Lgdel ^+/− and Dgcr8 ^+/− mice and their genotyping. Each cropped gel image reports two representative embryos from groups of animals genotyped for PGK/Neo (top left) and Idd/Hira alleles (bottom left) in (WT and Lgdel ^+/− embryos) or Cre (top right) and flox alleles (bottom right) in (Dgcr8 WT and Dgcr8 ^+/− embryos); “full-length gels are presented in Supplementary Figure S5”. (b) Overview of the experimental readouts used in this study, combining electrical measures and optical HCI. Scale bars represent 30 μm. (c) Workflow timeline of the experimental implementation.