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. 2017 Jun 16;5(4):435–447. doi: 10.1002/iid3.181

Figure 6.

Figure 6

Effects of FoxP3 as a post‐infection treatment target, assessed upon parasite load in E. multilocularis infected mice, and related T cell cytokine expression measured by qRT‐PCR. (A) Parasite load in AE‐DEREG DT‐ and AE‐DEREG DT+ mice assessed by wet weight measurement at 4 months post‐infection. DT application with 110 ng/mouse (three times/week) started 6 weeks post infection and was maintained until 4 months. (B) Il‐10 gene expression level in peritoneal and spleen cells from AE‐DEREG DT‐ and AE‐DEREG DT+ mice at 4 months post infection. (C) Ifn‐γ gene expression level in peritoneal and spleen cells from AE‐DEREG DT‐ and AE‐DEREG DT+ mice at 4 months post infection. (D) Il‐17a gene expression level in peritoneal and spleen cells from AE‐DEREG DT‐ and AE‐DEREG DT+ mice at 4 months post infection. Data represent mean ± SD of two independent experiments of a total of 8–10 mice in each group (4–5 mice per group in each independent experiment). Comparison between groups was performed using a one‐way ANOVA with Bonferroni's multiple comparison post‐test for statistical analysis. *p < 0.017. “WT,” wild type; “DEREG DT‐,” foxp3 inducible knock‐down mice (DEREG mice) without DT application; “DEREG DT+,” DEREG mice with DT application; “AE‐WT,” E. multilocularis‐infected wild type mice; “AE‐DEREG DT+,” E. multilocularis‐infected DEREG mice with DT application. “Control,” non‐infected mice; “1 m,” 1 month p.i.; “4 m,” 4 months p.i.. AU: arbitrary units.