Table 1.
Development of Peripheral Nerve Hyperexcitability with Aging in PLN Mutant Mice
| Muscle | Spontaneous activity |
|
|---|---|---|
| 2-month-old | 8-month-old | |
| Gastrocnemius | Absent | Intermittent |
| Paraspinal muscles | Intermittent | Continuous |
| Levator palpebrae | Intermittent | Continuous |
Seven PLN mice were surveyed from age 2 to 8 months by ENMG. The term intermittent describes spontaneous activity initiated by needle electrode movement or voluntary effort. The term continuous describes spontaneous activity that was recorded spontaneously. Spontaneous activity was never recorded in WT mice (n = 5).