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. 2012 Jan;180(1):221–234. doi: 10.1016/j.ajpath.2011.09.007

Figure 2.

Figure 2

Dietary EGCG dose dependently inhibits autoantigen-specific T-cell proliferation and DTH skin response. A: At day 60, after being fed and immunized with MOG35-55/CFA, as described in the legend to Figure 1, mice were euthanized and cells were isolated from the draining LNs. LN cells were restimulated with 0, 1, 10, or 100 μg/mL MOG35-55 peptide for 72 hours, and proliferation was determined by [3H]-thymidine incorporation. B: At day 57 (ie, 3 days before being euthanized), mice were rechallenged by injecting 20 μL of MOG35-55 peptide (10 μg/mL) into footpads, and DTH was measured as the thickness of footpads was recorded at 24, 48, and 72 hours after injection. Values are mean ± SEM (n = 6). *P < 0.05, **P < 0.01, and ***P < 0.001, as determined by one-way analysis of variance, followed by Tukey's honestly significant difference post hoc test for multiple comparisons.