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(A) Chemical structure of the thrombin-sensitive activatable cell-penetrating peptide (ACPP) constituted of a polycationic cell-penetrating peptide (blue) linked to a polyanionic inhibitory domain (orange) via a thrombin-sensitive substrate. The arrow indicates the site of cleavage of the peptide substrate by thrombin. (B) Schematic representation of the peptide cleavage yielding the polycationic cell-penetrating peptide.
